The role of clarithromycin in modern <i>Helicobacter pylori</i> eradication therapy regimens

Helicobacter pylori infection can serve as one of indications to clarithromycin prescription. H. eradication is performed commonly a treatment for diseases caused by this pathogen and conditions with an increased risk complications (precancerous changes the gastric mucosa, unspecified iron deficiency anemia, idiopathic thrombocytopenic purpura, long-term NSAIDs use, anti-platelet drugs use etc). A number functional characteristics determines specific requirements schemes: high sensitivity pathogen, ability antibacterial penetrate accumulate in tissue mucous,a stimulation microorganism’s reproduction protection acid-resistant reducing acid production well. If latter provided proton pump inhibitors, then fully provides other issues above. In Russia, standard triple therapy used first-line due current resistance less than 15%. The article gives detailed reasoning factual evidence commitment under increasing prevalence most recent antibiotic (local levofloxacin has reached 20%), potential multi-drug resistant strains appearing, low ensuring medical facilities relevant test-systems, role generic (clarithromycin inhibitors) compromised pharmaceutical creation erroneous interpretation pseudoresistance clarithromycin.